HGH (Human Growth Hormone) Release

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HGH (Human Growth Hormone)

HGH (Human Growth Hormone) Release

The pituitary releases human growth hormone (HGH) when it receives a signal from the brain’s hypothalamus in the form of growth hormone releasing hormone (GHRH). Release, however, can also be triggered by stress, exercise, emotional excitement, fasting, sleep, or hypoglycemia (low blood sugar). Release is inhibited by the hormone somatostatin and may be inhibited by lack of sleep, high blood sugar (hyperglycemia), obesity, a high blood level of free fatty acids, and by human growth hormone (HGH) itself. American endocrinologist Roger Guillemin and colleagues isolated somatostatin in 1973 and human growth hormone (HGH) releasing hormone (at that time called growth hormone releasing factor; now known to be a hormone) in 1984. Reference

Growth hormone–releasing hormone (GHRH), also known as somatoliberin or by several other names in its endogenous forms and as somatorelin (INN) in its pharmaceutical form, is a releasing hormone of human growth hormone (HGH). It is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus. GHRH first appears in the human hypothalamus between 18 and 29 weeks of gestation, which corresponds to the start of production of human growth hormone (HGH) and other somatotropes in fetuses. GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal system to the anterior pituitary gland, where it stimulates ghuman growth hormone (HGH) secretion by stimulating the growth hormone-releasing hormone receptor. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly. human growth hormone (HGH) is required for normal postnatal growth, bone growth, regulatory effects on protein, carbohydrate, and lipid metabolism. Reference

Gowth hormone-releasing hormone (GHRH), a large peptide hormone that exists in several forms that differ from one another only in the number of amino acids, which can vary from 37 to 44. Unlike other neurohormones increases in response to physical and emotional stress, and its secretion is blocked by a powerful hypothalamic neurohormone called somatostatin. The secretion of GHRH is also inhibited by insulin-like growth factors, which are generated when tissues are exposed to human growth hormone (HGH) itself. Ghrelin, a 28-amino-acid peptide, is a hypothalamic substance that acts synergistically with GHRH to increase growth hormone secretion. Ghrelin may also stimulate the secretion of GHRH and inhibit the secretion of somatostatin. The physiologic role of ghrelin in the regulation of human growth hormone (HGH) secretion is not known. Reference