HGH (Human Growth Hormone) Function

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HGH (Human Growth Hormone)

HGH (Human Growth Hormone) Function

Effects of human growth hormone (HGH) on the tissues of the body can generally be described as anabolic (building up). Like most other protein hormones, human growth hormone (HGH) acts by interacting with a specific receptor on the surface of cells. Increased height during childhood is the most widely known effect of human growth hormone (HGH). Height appears to be stimulated by at least two mechanisms: Because polypeptide hormones are not fat-soluble, they cannot penetrate cell membranes. Thus, human growth hormone (HGH) exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway. Through this mechanism human growth hormone (HGH) directly stimulates division and multiplication of chondrocytes of cartilage. Reference

Human growth hormone (HGH) also stimulates, through the JAK-STAT signaling pathway, the production of insulin-like growth factor 1 (IGF-1, formerly known as somatomedin C), a hormone homologous to proinsulin. The liver is a major target organ of human growth hormone (HGH) for this process and is the principal site of IGF-1 production. IGF-1 has growth-stimulating effects on a wide variety of tissues. Additional IGF-1 is generated within target tissues, making it what appears to be both an endocrine and an autocrine/paracrine hormone. IGF-1 also has stimulatory effects on osteoblast and chondrocyte activity to promote bone growth. Reference

Human growth hormone (HGH) acts on many parts of the body to promote growth in children. In adults, it does not cause growth but it helps to maintain normal body structure and metabolism, including helping to keep blood glucose levels within set levels. Human growth hormone (HGH) secretion and serum IGF-1 concentrations decrease gradually with age. As compared with young adults, older people have mild deficiency of growth hormone and IGF-1. Deficiency of IGF-1 could help to explain the decrease of muscle mass and the increase in fat mass that occurs in many older people. Whether human growth hormone (HGH) treatment reverses these changes is controversial, and the treatment has potentially dangerous side effects, including increased blood pressure and fluid retention. Reference