HGH (Human Growth Hormone) deficiency

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HGH (Human Growth Hormone)

HGH (Human Growth Hormone) deficiency

The effects of human growth hormone (HGH) deficiency vary depending on the age at which they occur. In children, growth failure and short stature are the major manifestations of human growth hormone (HGH) deficiency, with common causes including genetic conditions and congenital malformations. It can also cause delayed sexual maturity. In adults, deficiency is rare, with the most common cause a pituitary adenoma, and others including a continuation of a childhood problem, other structural lesions or trauma, and very rarely idiopathic GHD. Adults with GHD “tend to have a relative increase in fat mass and a relative decrease in muscle mass and, in many instances, decreased energy and quality of life”. Reference

Human growth hormone (HGH) deficiency has a variety of different negative effects at different ages; for example, in newborn infants, the primary manifestations may be hypoglycemia or micropenis, while in later infancy and childhood, growth failure is more likely. Deficiency in adults is rare, but may feature diminished lean body mass, poor bone density, and a number of physical and psychological symptoms. Psychological symptoms include poor memory, social withdrawal, and depression, while physical symptoms may include loss of strength, stamina, and musculature. Other hormonal or glandular disorders frequently coincide with diminished human growth hormone (HGH) production. Reference

Human growth hormone (HGH) deficiency is one of the many causes of short stature and dwarfism. It results primarily from damage to the hypothalamus or to the pituitary gland during fetal development (congenital human growth hormone (HGH) deficiency) or following birth (acquired human growth hormone (HGH) deficiency). Human growth hormone (HGH) deficiency may also be caused by mutations in genes that regulate its synthesis and secretion. Affected genes include PIT-1 and POUF-1. Mutations in these genes may also cause decreased synthesis and secretion of other pituitary hormones. In some cases, Human growth hormone (HGH) deficiency is the result of GHRH deficiency, in which case Human growth hormone (HGH) secretion may be stimulated by infusion of GHRH. In other cases, the somatotrophs themselves are incapable of producing Human growth hormone (HGH), or the hormone itself is structurally abnormal and has little growth promoting activity. In addition, short stature and GH deficiency are often found in children diagnosed with psychosocial dwarfism, which results from severe emotional deprivation. When children with this disorder are removed from the stressing, non nurturing environment, their endocrine function and growth rate normalize. Reference